Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells
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چکیده
منابع مشابه
urtica dioica effect on malonyl-coa decarboxylase
background the malonyl-coa decarboxylase (mcd, ec.4.1.1.9) enzyme regulates malonyl-coa levels. the effect of aerial parts extracts of urtica dioica (ud) on mcd is poorly understood. objectives the present experiment was undertaken to evaluate the effect of ud aerial parts extracts on mcd level. materials and methods in this experimental study, two groups of rats were used: normal and hyperglyc...
متن کاملEffects of Teucrium polium aerial parts extracts on malonyl-CoA decarboxylase level
Malonyl-CoA decarboxylase (MCD) is an enzyme involved in the decarboxylation of malonyl-CoA to acetyl-CoA. In order to explore the hypothesis that the changing plant materials’ MCD activity level can serve as therapy to diabetics, the effect of Teucrium polium compounds was studied in a diabetic rat model. In this experimental study, two groups of rats, a control and a diabetic group, each incl...
متن کاملHeteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.
A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts.
متن کاملMalonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase.
Although the malonyl-CoA sensitivity of peroxisomal carnitine octanoyltransferase (COT) is reportedly lost on solubilization, we show that malonyl-CoA does inhibit the purified enzyme. Assay conditions such as buffer composition, pH, acyl-CoA substrate and the presence or absence of BSA can affect the observed inhibition. When assayed in the absence of BSA, COT shows simple competitive inhibiti...
متن کاملGummosin, a sesquiterpene coumarin from Ferula assa-foetida is preferentially cytotoxic to human breast and prostate cancer cell lines
Objective: The present study was conducted to find cytotoxic compounds from oleo-gum-resin of Ferula assa-foetida (asafoetida). Materials and Methods: A di...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2009
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2009.160